Tropine acyltransferase (, ''tropine:acyl-CoA transferase'', ''acetyl-CoA:tropan-3-ol acyltransferase'', ''tropine acetyltransferase'', ''tropine tigloyltransferase'', ''TAT'') is an
enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...
with
systematic name A systematic name is a name given in a systematic way to one unique group, organism, object or chemical substance, out of a specific population or collection. Systematic names are usually part of a nomenclature.
A semisystematic name or semitrivial ...
''acyl-CoA:tropine O-acyltransferase''.
This enzyme
catalyses the following
chemical reaction
A chemical reaction is a process that leads to the IUPAC nomenclature for organic transformations, chemical transformation of one set of chemical substances to another. Classically, chemical reactions encompass changes that only involve the pos ...
:
acyl-CoA
Acyl-CoA is a group of coenzymes that metabolize fatty acids. Acyl-CoA's are susceptible to beta oxidation, forming, ultimately, acetyl-CoA. The acetyl-CoA enters the citric acid cycle, eventually forming several equivalents of ATP. In this way ...
+
tropine
Tropine is a derivative of tropane containing a hydroxyl group at the third carbon. It is also called 3-tropanol.
Tropine is a central building block of many chemicals active in the nervous system, including tropane alkaloids. Some of these comp ...
CoA + O-acyltropine
This enzyme exhibits absolute specificity for the endo/3alpha configuration found in tropine as
pseudotropine
Pseudotropine (3β-tropanol, ψ-tropine, 3-pseudotropanol, or PTO) is a derivative of tropane and an isomer of tropine. Pseudotropine can be found in the ''Coca'' plant along with several other alkaloids
See also
* Pseudotropine acyltransfe ...
.
References
External links
*
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EC 2.3.1